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In vivo hemming av MicroRNA å redusere tumor vekst i mus
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
DOI:

00:07 min

August 23, 2019

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Chapters

  • 00:04Title
  • 00:49Flank Inoculation and Intratumoral AntagomiR Treatment
  • 02:23Tumor Growth Analysis
  • 03:10Thyroid Orthotopic Inoculation and Systemic AntagomiR Treatment
  • 05:05Results: Representative Effects of In Vivo MicroRNA Inhibition on Tumor Growth in Mice
  • 06:42Conclusion

Summary

Automatic Translation

Denne protokollen beskriver xenograft og orthotopic musemodeller av Human thyroid tumorigenesis som en plattform for å teste microRNA-baserte inhibitor behandlinger. Denne tilnærmingen er ideell for å studere funksjonen av ikke-koding RNAs og deres potensial som nye terapeutiske mål.

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