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Neuroscience
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大鼠中枢神经系统中反义寡核苷酸的细胞内传递
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
Please note that all translations are automatically generated.
Click here for the English version.
大鼠中枢神经系统中反义寡核苷酸的细胞内传递
DOI:
10.3791/60274-v
•
07:47 min
•
October 29, 2019
•
Chapters
00:04
Title
00:46
Material and Instrument Preparation
02:09
Surgery Preparation
03:05
Surgery
06:53
Results: A Single Bolus Antisense Oligonucleotide (ASO) Intrathecal Injection Reduces Rat Malat1 In Vivo
07:17
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们描述了一种通过将导管植入脊柱的腰间空间来向大鼠中枢神经系统输送药物的方法。我们专注于反义寡核苷酸的输送,尽管这种方法也适合其他治疗方式的交付。
Tags
Intrathecal Delivery
Antisense Oligonucleotides
Rat Central Nervous System
Pharmacokinetics
Pharmacodynamics
Efficacy
Guide Cannula
Catheter Wire Assembly
Delivery Catheter Assembly
Guide Cannula-needle Assembly
Spinal Cord Injection
Buprenorphine
Surgical Procedure
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