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Cancer Research

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JoVE Journal Cancer Research
Het in kaart brengen van de structuur-functierelaties van ongeordende oncogene transcriptiefactoren met behulp van transcriptomische analyse
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Het in kaart brengen van de structuur-functierelaties van ongeordende oncogene transcriptiefactoren met behulp van transcriptomische analyse

Article DOI: 10.3791/61564-v • 09:58 min • June 27th, 2020
June 27th, 2020 •
1,2, 1, 1, 1, 1,3, 1,4
1Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, 2Molecular, Cellular, and Developmental Biology Program, The Ohio State University, 3Division of Pediatric Hematology/Oncology/Blood & Marrow Transplant, The Ohio State University, 4Department of Pediatrics, The Ohio State University

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Intrinsiek ongeordende domeinen zijn belangrijk voor de functie van de oncogene fusietranscriptiefactor. Om deze eiwitten therapeutisch te targeten, is een meer gedetailleerd begrip van de regulerende mechanismen die door deze domeinen worden gebruikt, vereist. Hier gebruiken we transcriptomics om belangrijke structurele kenmerken van het intrinsiek ongeordende EWS-domein in Ewing-sarcoom in kaart te brengen.

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Cancer Research transcriptomics RNA-seq structure-function transcriptiefactoren intrinsiek ongeordende domeinen EWS/FLI Ewing-sarcoom genregulatie
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