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Kapillær elektroforesebaseret hydrogen/deuteriumudveksling til konformationskarakterisering af proteiner med top-down massespektrometri
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Kapillær elektroforesebaseret hydrogen/deuteriumudveksling til konformationskarakterisering af proteiner med top-down massespektrometri

Article DOI: 10.3791/62672-v • 05:45 min • June 8th, 2021
June 8th, 2021 •
1,2, 1, 1,2, 1, 3, 1
1School of Chemistry and Materials Science, Nanjing Normal University, 2Institute for Cell Analysis, Shenzhen Bay Laboratory, 3Department of Chemistry, University of British Columbia

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Præsenteret her er en protokol for en kapillær elektroforesebaseret hydrogen / deuterium udveksling (HDX) tilgang kombineret med top-down massespektrometri. Denne tilgang karakteriserer forskellen i højere ordens strukturer mellem forskellige proteinarter, herunder proteiner i forskellige tilstande og forskellige proteoformer, ved at udføre samtidig differentiel HDX og elektroforetisk adskillelse.

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