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JoVE Journal
Bioengineering

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Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
 

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System

Article DOI: 10.3791/50866-v 11:04 min October 16th, 2013
October 16th, 2013

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Summary

This study used a multi-well plate microfluidic system, significantly increasing throughput of cell rolling studies under physiologically relevant shear flow. Given the importance of cell rolling in the multi-step cell homing cascade and the importance of cell homing following systemic delivery of exogenous populations of cells in patients, this system offers potential as a screening platform to improve cell-based therapy.

Tags

In Vitro Cell Rolling Multi-well Plate Microfluidic System Cell-based Therapy Cell Homing Vascular Endothelium Parallel Plate Flow Chamber (PPFC) Multi-parameter Software Analysis Platform Rolling Velocities Rolling Path HL-60 Cells P-selectin E-selectin Tumor Necrosis Factor-alpha (TNF-alpha) Endothelial Cells (ECs)
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