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Journal / Genetics / CRISPR-medieret reorganisering af kromatin løkke…
JoVE Journal
Genetics

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CRISPR-medieret reorganisering af kromatin løkke struktur
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CRISPR-medieret reorganisering af kromatin løkke struktur

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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Kromatin looping spiller en væsentlig rolle i genregulering; der har dog været nogen teknologiske fremskridt, som giver mulighed for selektiv og reversible ændring af kromatin sløjfer. Her beskriver vi et kraftfuldt system for kromatin loop re organisation ved hjælp af CRISPR-dCas9 (CLOuD9), viste at selektivt og reversibelt modulere genekspression på målrettet loci.

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Genetik sag 139 kromatin sløjfer kromatin foldning gene expression CRISPR dCas9 genregulering vendbar dimerization dynamisk kromosomal omrokering.
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