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创建小鼠实验与弹性蛋白酶的腹主动脉瘤
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JoVE Journal Biology
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
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创建小鼠实验与弹性蛋白酶的腹主动脉瘤

DOI:
10.3791/1280-v

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10:23 min

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July 23, 2009

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, , ,
1Department of Cardiovascular Medicine,Stanford University School of Medicine, 2Department of Vascular Surgery,Stanford University School of Medicine

Chapters

  • 00:05Title
  • 00:57Introduction
  • 01:31Preparing the Mouse for Surgery
  • 03:16Surgical Prodcedure
  • 09:20Representative Results
  • 09:50Conclusion

Summary

Automatic Translation

Automatic Translation

该视频演示了如何通过瞬态下腹段腹主动脉腔内灌注到猪胰弹性蛋白酶诱导小鼠腹主动脉瘤（AAA）的。该模型已添加到AAA的病理学由于出现了大量的转基因和基因敲除小鼠的广泛的洞察力的能力。

Tags

MurineExperimentalAbdominal Aortic AneurysmsElastaseIntraluminal InfusionPorcine Pancreatic ElastaseInfrarenal SegmentAbdominal AortaAnimal ModelDisrupted Nature Of ElastinPathobiology Of AAATransgenic MiceGene Knockout MiceTherapeutic AgentsElastase Infusion AAA ProcedureLaparotomySterile ConditionsOperating StereomicroscopeLigaturesAortotomyPolyethylene TubingPerfusion Catheter

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