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内向整流钾通道的小分子调节剂的高通量筛选
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High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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内向整流钾通道的小分子调节剂的高通量筛选

DOI:
10.3791/4209-v

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10:07 min

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January 27, 2013

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, ,
1Department of Pharmacology,Vanderbilt University School of Medicine, 2Department of Anesthesiology,Vanderbilt University School of Medicine, 3Vanderbilt Institute of Chemical Biology,Vanderbilt University School of Medicine

Chapters

  • 00:05Title
  • 01:23General Thallium Flux Assay Procedure
  • 05:04Checkerboard Analysis
  • 07:22Results: High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
  • 09:27Conclusion

Summary

Automatic Translation

Automatic Translation

开发和验证测量活动的高通量化合物筛选的内向整流钾通道（基里巴斯）荧光定量检测方法。

Tags

High-throughput ScreeningSmall-molecule ModulatorsInward Rectifier Potassium ChannelsDrug TargetsPharmacological ToolsMolecular PharmacologyS4 SuperfamilyVoltage-gated Potassium ChannelsPeptide Toxin ModulatorsBee Venom Toxin TertiapinKir1.1Kir3 ChannelsAntigenic PropertiesPoor BioavailabilityMetabolic StabilitySmall-molecule ProbesPhysiologyTherapeutic Potential

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