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Biology
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内向整流钾通道的小分子调节剂的高通量筛选
JoVE Journal
Biology
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JoVE Journal
Biology
High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Please note that all translations are automatically generated.
Click here for the English version.
内向整流钾通道的小分子调节剂的高通量筛选
DOI:
10.3791/4209-v
•
10:07 min
•
January 27, 2013
•
Rene Raphemot
2
,
C. David Weaver
3
,
Jerod S. Denton
2
1
Department of Pharmacology
,
Vanderbilt University School of Medicine
,
2
Department of Anesthesiology
,
Vanderbilt University School of Medicine
,
3
Vanderbilt Institute of Chemical Biology
,
Vanderbilt University School of Medicine
Chapters
00:05
Title
01:23
General Thallium Flux Assay Procedure
05:04
Checkerboard Analysis
07:22
Results: High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
09:27
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
开发和验证测量活动的高通量化合物筛选的内向整流钾通道(基里巴斯)荧光定量检测方法。
Tags
High-throughput Screening
Small-molecule Modulators
Inward Rectifier Potassium Channels
Drug Targets
Pharmacological Tools
Molecular Pharmacology
S4 Superfamily
Voltage-gated Potassium Channels
Peptide Toxin Modulators
Bee Venom Toxin Tertiapin
Kir1.1
Kir3 Channels
Antigenic Properties
Poor Bioavailability
Metabolic Stability
Small-molecule Probes
Physiology
Therapeutic Potential
Article
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