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携帯の障壁を通過する薬物送達システムの輸送を評価するためのモデルと方法
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
DOI:

18:57 min

October 17, 2013

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Chapters

  • 00:05Title
  • 03:09Culturing a Cell Monolayer in Transwell Inserts
  • 04:34Validation of the GI Epithelial Permeability Barrier using Transepithelial Electrical Resistance (TEER) and Immunostaining of Tight Junctions
  • 06:29Evaluating Transepithelial Transport of Targeted Carriers
  • 10:25Investigating the Mechanism of Transepithelial Transport of Targeted Nanocarriers
  • 12:36Results: Caco-2 Cell Monolayer is a Model of Transepithelial Transport of Drug Nanocarriers (NCs) Across Cellular Barriers
  • 17:50Conclusion

Summary

Automatic Translation

多くの治療用途は、体内の細胞の壁を越え薬物担体とその貨物の安全かつ効率的な輸送を必要とする。この記事では、胃腸(GI)上皮のような細胞壁を越えた薬物ナノキャリア(NCS)の輸送速度とメカニズムを評価するために確立された方法の適応を説明します。

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