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Biology

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In vitro Aggregation assays under anvendelse af hyperphosphoryleret tau-protein
 
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In vitro Aggregation assays under anvendelse af hyperphosphoryleret tau-protein

Article DOI: 10.3791/51537
January 2nd, 2015

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Summary January 2nd, 2015

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Umodificerede og hyperphosphorylerede tau-proteiner blev anvendt i to in vitro aggregation assays til at afsløre hyperphosphoryleringsbegivenheder-afhængige hurtig sammenlægning kinetik. Disse assays bane vejen for fremtidige skærme for forbindelser, der kan modulere tilbøjelighed hyperphosphoryleret tau at danne fibriller, der ligger til grund for progressionen af ​​Alzheimers sygdom.

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