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In vitro Aggregation assays under anvendelse af hyperphosphoryleret tau-protein
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In vitro Aggregation assays under anvendelse af hyperphosphoryleret tau-protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Umodificerede og hyperphosphorylerede tau-proteiner blev anvendt i to in vitro aggregation assays til at afsløre hyperphosphoryleringsbegivenheder-afhængige hurtig sammenlægning kinetik. Disse assays bane vejen for fremtidige skærme for forbindelser, der kan modulere tilbøjelighed hyperphosphoryleret tau at danne fibriller, der ligger til grund for progressionen af ​​Alzheimers sygdom.

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Biokemi tau Alzheimers sygdom tauopati phosphorylering amyloid lynlåse-Assisted Katalyse proteinaggregering neurofibrillære sammenfiltringer
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