Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Baozhen Zhang; Zhilong Chen; Jinyu Han; Mengxia Li; Nihar R. Nayak; Xiujun Fan

doi:10.3791/58219

Journal

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Bioengineering

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Avaliação global da eficácia e segurança de entrega de droga Placenta-alvo usando três métodos complementares

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Avaliação global da eficácia e segurança de entrega de droga Placenta-alvo usando três métodos complementares

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9,647 Views

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09:04 min

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September 10, 2018

DOI:

10.3791/58219-v

DOI:

10.3791/58219-v

•

09:04 min

September 10, 2018

•

2 Views

Baozhen Zhang¹, Zhilong Chen^1,2, Jinyu Han^1,3, Mengxia Li¹, Nihar R. Nayak⁴, Xiujun Fan¹

¹Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, ²College of Veterinary Medicine,Hunan Agricultural University, ³Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences,Heilongjiang University, ⁴Department of Obstetrics and Gynecology,Wayne State University School of Medicine

Transcript

Summary

Descrevemos um sistema que utiliza três métodos para avaliar a segurança e a eficácia da entrega da droga placenta-alvo: no vivo de imagem para monitorar o acúmulo de nanopartículas, ultra-som de alta frequência para monitorar o desenvolvimento placentário e fetal e HPLC para quantificar a entrega da droga ao tecido.