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由康卡纳林注射到乳原区引起的水性干眼病的兔子模型：药物功效研究的应用
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
Please note that all translations are automatically generated.
Click here for the English version.
由康卡纳林注射到乳原区引起的水性干眼病的兔子模型：药物功效研究的应用
DOI:
10.3791/59631-v
•
08:04 min
•
January 24, 2020
•
Robert A. Honkanen
,
Liqun Huang
3
,
Basil Rigas
1
Department of Ophthalmology
,
Stony Brook University
,
2
Department of Preventive Medicine
,
Stony Brook University
,
3
Medicon Pharmaceuticals, Inc.
Chapters
00:04
Title
01:25
Nictitating Membrane Injection and Removal
02:41
Dry Eye Induction
06:15
Results: Representative Effects of Aqueous-Deficient Dry Eye Disease (DED) Induction
07:19
Conclusion
Summary
Automatic Translation
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Automatic Translation
本文介绍了一种方法，通过注射结沙蛋白A到轨道乳腺系统的所有部分来诱发兔子急性或慢性干眼病。该方法优于已经报告的方法，产生了一种可重复的、稳定的干眼模型，适合药理剂的研究。
Tags
Keywords: Rabbit Model
Aqueous-deficient Dry Eye Disease
Concanavalin A
Lacrimal Gland Injection
Ultrasound Guidance
Animal Model
Drug Efficacy Studies
Pathophysiology
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