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Biology

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结合表观遗传修饰和生物力学线索的两步策略,以产生哺乳动物多能细胞
 
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结合表观遗传修饰和生物力学线索的两步策略,以产生哺乳动物多能细胞

Article DOI: 10.3791/61655-v 08:01 min August 29th, 2020
August 29th, 2020

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Summary

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Click here for the English version.

我们在这里提出了一种将化学表观遗传擦除与机械检测相关线索相结合的方法,以有效地产生哺乳动物多能细胞,而无需基因转染或逆转录病毒载体。因此,这种策略对转化医学很有希望,并且代表了干细胞类器官技术的显着进步。

Tags

生物学, 问题 162, 5-aza-CR, 3D 培养系统, 表观遗传擦除, 成纤维细胞, 机械检测相关线索, 多能性, PTFE 微生物反应器
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