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Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
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JoVE Journal Neuroscience
Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

DOI:
10.3791/62536-v

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06:07 min

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May 06, 2021

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, ,
1Institute for Stroke and Dementia Research,LMU Munich, 2Munich Cluster for Systems Neurology (SyNergy)

Chapters

  • 00:04Introduction
  • 00:56Equipment Set-up and Animal Preparation
  • 02:08Photo-Thrombosis Surgery
  • 03:48Results: Analysis of the Mice After Photothrombotic Surgery
  • 05:30Conclusion

Summary

Automatic Translation

Automatic Translation

Described here is the photothrombotic stroke model, where a stroke is produced through the intact skull by inducing permanent microvascular occlusion using laser illumination after administration of a photosensitive dye.

Tags

Keywords: PhotothrombosisStroke ModelCortical PlasticityRose BengalLaserFocal Cortical LesionsMouse ModelAnesthesiaSurgical ProcedureTemperature Control

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