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JoVE Journal Neuroscience
En enkel metode til at fremkalde eksperimentelle Autoimmune Neuritis i C57BL/6 mus for funktionelle og neuropatologiske vurderinger
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En enkel metode til at fremkalde eksperimentelle Autoimmune Neuritis i C57BL/6 mus for funktionelle og neuropatologiske vurderinger

Article DOI: 10.3791/56455 • 07:30 min • November 9th, 2017
November 9th, 2017 •
1, 1, 1, 1, 1, 1
1Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne

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Denne betænkning skitserer en enkel tilgang for at med held fremkalde eksperimentelle autoimmune neuritis (EAN) ved hjælp af myelin protein nul (P0)180-199 peptid i kombination med Freunds komplet adjuvans og pertussis toksin. Vi præsenterer en sofistikeret paradigme i stand til præcist at vurdere omfanget af funktionelle mangler og neuropatologiske, der forekommer i denne EAN.

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Neurovidenskab sag 129 eksperimentelle autoimmune neuritis cytoskeletale skader noder af Ranvier perifer nerve demyelinering musemodel
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