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JoVE Journal
Immunology and Infection

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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
 

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Article DOI: 10.3791/51222
May 5th, 2014

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Summary May 5th, 2014

In vitro assays to measure virus replication have been greatly improved by the development of recombinant RNA viruses expressing luciferase or other enzymes capable of bioluminescence. Here we detail a high-throughput screening pipeline that combines such recombinant strains of measles and chikungunya viruses to isolate broad-spectrum antivirals from chemical libraries.

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