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JoVE Journal Neuroscience
In Vitro Kile skive Forberedelse for å etterligne In Vivo Neuronal Circuit Connectivity
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In Vitro Kile skive Forberedelse for å etterligne In Vivo Neuronal Circuit Connectivity

Article DOI: 10.3791/61664-v • 10:31 min • August 18th, 2020
August 18th, 2020 •
1, 1
1Section on Neuronal Circuitry, National Institute on Deafness and Other Communication Disorders, NIH

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Integrering av ulike synaptiske innganger til nevroner måles best i et preparat som bevarer alle presynaptiske kjerner for naturlig timing og kretsplastisitet, men hjerneskiver som vanligvis bryte mange tilkoblinger. Vi utviklet en modifisert hjerneskive for å etterligne in vivo kretsaktivitet samtidig som in vitro eksperimenteringsevne.

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Nevrovitenskap utgave 162 mediale olivocochlearonroner in vitro skive elektrofysiologi synaptisk integrasjon auditiv nerve auditiv hjernestamme cochleakjerne hemmende nevrotransmisjon
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